What should I expect during a rejuran polynucleotide injection procedure?

What to Expect During a Rejuran Polynucleotide Injection Procedure

During a Rejuran polynucleotide injection procedure, you can expect a multi-step process that typically takes 30 to 60 minutes. It begins with a thorough consultation and skin analysis, followed by cleansing, the optional application of a topical numbing cream for about 20-30 minutes, and the injection process itself where the product is strategically delivered into the dermal layer of your skin using fine needles or cannulas. You might feel mild, fleeting pricks or a slight pressure. Aftercare instructions are then provided to ensure optimal results. The procedure is minimally invasive with little to no downtime, designed to stimulate your skin’s natural healing and collagen production processes from within.

Let’s break down that journey into the high-density details so you know exactly what’s happening at each stage, from the moment you walk into the clinic to the days that follow.

The Pre-Procedure Consultation: Your Personalized Blueprint

This isn’t just a formality; it’s the most critical part of the entire process. A reputable practitioner will spend a significant amount of time—often 20 to 30 minutes—to understand your goals, medical history, and skin concerns. They will assess your skin type, elasticity, and the specific areas you want to address, such as fine lines, acne scars, or overall skin laxity. This is when they create a tailored treatment plan. They’ll determine the appropriate dilution of the Rejuran polynucleotide solution (often mixed with saline or a local anesthetic like lidocaine) and map out the exact injection points on your face. This mapping is crucial for ensuring even distribution and natural-looking results. They should also clearly explain the science: that Rejuran is derived from salmon DNA, is highly purified, and works by providing bio-stimulatory cues to your skin cells, encouraging them to repair and regenerate. This is your chance to ask every question you have. A trustworthy clinic, like the one you can find at rejuran, will prioritize this educational step.

Preparation and Numbing: Setting the Stage for Comfort

Once you’re in the treatment room, the actual hands-on preparation begins. The clinician will thoroughly cleanse your face with an antiseptic solution to eliminate any surface bacteria, significantly reducing the risk of infection. Next comes numbing. While the needles used are exceptionally fine (typically 30 to 32-gauge), many practitioners apply a topical numbing cream to maximize comfort. This cream needs time to work—usually 20 to 30 minutes. It’s left on until your skin feels slightly numb to the touch. Some clinics may even offer a nerve block, which is a more profound local anesthesia, for those who are particularly sensitive or undergoing a more extensive treatment. The table below outlines the typical preparation timeline.

The Injection Technique: Precision in Motion

This is the core of the procedure. The practitioner will use either a very fine needle or a blunt-tipped cannula. The choice depends on the target area and the practitioner’s preference. Needles allow for very precise, pinpoint injections, ideal for treating specific acne scars. Cannulas are flexible tubes that can be navigated under the skin with a single entry point, which can reduce bruising and is often used for broader areas like the cheeks for overall rejuvenation.

The technique itself is highly specific. The most common method is the linear threading or fanning technique, where the practitioner injects the product in multiple linear tracks or in a fan-like pattern just below the skin’s surface (the dermis). You will hear a faint popping sound as the needle or cannula enters the skin. The sensation is often described as a quick, sharp prick followed by a slight burning or pressure as the solution is deposited. A typical session for a full-face treatment involves anywhere from 50 to 100+ individual injections, meticulously placed about 1-2 cm apart. The practitioner will frequently pause to assess symmetry and ensure even distribution.

Immediate Aftermath and Sensations

Right after the injections are complete, your face will not look “done.” In fact, it will look quite the opposite. It’s normal and expected to see:

• Erythema (Redness): The skin will be significantly red and flushed, similar to a moderate sunburn. This is due to the controlled trauma of the needles and the initial inflammatory response that kick-starts the healing process.
• Edema (Swelling): You will experience swelling, which can be quite pronounced, especially around the eyes and cheeks if those areas were treated. The skin may feel tight and look puffy.
• Papules (Small Bumps): At each injection site, you will likely see and feel small, white bumps or papules. This is a good sign. It indicates that the product has been correctly placed in the dermis. These bumps typically subside within 24 to 48 hours as the polynucleotide solution integrates with your skin tissue and begins hydrating the area.
• Minor Bleeding/Bruising: Some pinpoint bleeding is common and will be wiped away. Bruising can occur, especially if you are prone to it or if you’ve taken blood-thinning medications (which you should have disclosed during the consultation).

The practitioner will often apply a soothing serum and a cooling mask or use a cold air device to help calm the skin immediately after the procedure.

The Crucial First 72 Hours: Your At-Home Aftercare

What you do in the first three days is instrumental in determining how quickly you recover and how effective the treatment will be. The primary goal is to manage the inflammatory response without stifling it, as inflammation is a necessary part of the regenerative process.

Do:

• Ice Gently: Use a cold pack wrapped in a clean cloth for 10-15 minutes every hour for the first 4-6 hours to reduce swelling.
• Sleep Elevated: Use an extra pillow for the first two nights to help drain fluid from your face and minimize morning swelling.
• Use Gentle Cleansers: Cleanse your face with a mild, non-exfoliating cleanser and lukewarm water. Pat dry, don’t rub.
• Apply Recommended Moisturizers: Use any post-procedure ointments or hydrators provided by your clinician.
• Stay Hydrated: Drink plenty of water to help your body’s healing mechanisms.

Don’t:

• Exercise Intensely: Avoid anything that raises your blood pressure and heart rate for at least 48 hours, as this can worsen swelling and bruising.
• Apply Makeup: Avoid makeup for at least 24 hours to let the microscopic injection channels close and reduce infection risk.
• Expose Skin to Heat: No hot showers, saunas, steam rooms, or direct sunlight for at least 48 hours.
• Touch or Massage Your Face: Do not rub, press, or massage the treated areas unless specifically instructed by your practitioner.

By day 3, the significant redness and swelling should have subsided considerably, and the papules should be barely noticeable. You can usually resume your normal skincare routine and wear makeup if needed.

Beyond the First Week: The Science of Transformation

The immediate effects you see after the swelling goes down are primarily due to intense skin hydration from the polynucleotides. However, the true magic of Rejuran is a slow, biological unfolding over the following weeks and months. The polynucleotide chains act as signaling molecules, directing your fibroblasts (the collagen-producing cells in your skin) to become more active. This isn’t just adding volume; it’s remodeling your skin’s foundation.

Here’s a typical timeline of what to expect biologically and visually:

Most practitioners recommend a series of treatments—usually 3 sessions spaced 4 weeks apart—to achieve cumulative and long-lasting results. The stimulated collagen can continue to improve the skin’s quality for up to 6 months after the last session.